lymphoid hyperplasia base of tongue

The base of tongue refers to the back one-third of the tongue that continues down the throat. All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. Squamous cell hyperplasia in the oral cavity is seen most commonly on the tongue, palate, and lateral wall of the pharynx. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Careers. Rasmussen PK. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. FOIA 2005;9:34050. DLBCL with high risk factors and MCL may have unfavourable outcomes. Chang CC, Liu YC, Cleveland RP, Perkins SL. Acta Oncol. Acta Ophthalmol. f. Tumour cells were negative for CD8 (200x). Lailatul et al. The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3]. Results came back "lymphoid hyperplasia". One patient in the literature died 18months after diagnosis despite being in an early stage. The tissue demonstrates a polarized mantle zone beneath a somewhat attenuated epithelium. We not only report on the general clinicopathological features, including age, gender, tumour location, histological subtypes, grading and staging, but also provide important information related to prognosis and treatment. Most of these cancers are squamous cell carcinoma and caused by human papillomavirus (HPV) infection. A. Kolokotronis, I. Dimitrakopoulos, and A. Asimaki, Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. https://doi.org/10.1016/j.ijom.2004.08.009. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Virchows Arch. Careers. Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F. Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity. As they mount an immune response, lymphoid cells can proliferate and enlarge. The airway was subsequently secured, and the procedure was undertaken. Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. The etiology is poorly understood, although some authors have postulated a relationship with chronic irritation (i.e., reflux, poorly fitting dentures, etc.) In this paper we present a case of severe pharyngeal lymphoid hyperplasia causing airway obstruction and requiring tracheotomy and subsequent surgical debulking. Google Scholar. Accessibility The tumour cells were large and blastic, with a high mitotic rate, which was similar to diffuse large B lymphoma tumour cells. https://doi.org/10.1093/annonc/mdl131. Radiology. Am J Gastroenterol. 1991;6(3):170-8. doi: 10.1007/BF02493520. She was awarded the Dental Professional of the Year in 2017 through the International Pemphigus and Pemphigoid Foundation and is a 2017 Sunstar/RDH Award of Distinction recipient. Then he looked down my throat through my nose. Accessibility The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. National Library of Medicine Clinical and laboratory investigations are routinely negative [2]. The clinical stage was IV A by the Ann Arbor staging system. Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. 2017;30:S4453. The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring. These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. c. Some tumour cells were medium-sized with a clear cytoplasm (200x). In contrast, they did not express CD3, CD10, CD23, or TdT. Paracortical hyperplasia may be accompanied by vascular proliferation. Oral-cutaneous CD4-positive T-cell lymphoma: a study of two patients. J Oral Maxillofac Pathol. Sun J, Lu Z, Yang D, Chen J. The population of the compartment is cytologically polymorphous. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. M. Samoszuk, E. Ramzi, and J. Ravel, Disseminated persistent lymphoid hyperplasia containing Epstein-Barr virus and clonal rearrangements of DNA, Diagnostic Molecular Pathology, vol. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. On this Wikipedia the language links are at the top of the page across from the article title. Tumours in this site are predominantly DLBCL subtypes in histology. Am J Surg Pathol. Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. Discussions concentrating on NHL of the base of the tongue have focused on the histopathology and lack details regarding progress in the treatment response and prognosis. 8600 Rockville Pike government site. This patient had a partial response to chemotherapy and died 63months after diagnosis. 88, no. 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. Two patients survived more than six years. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). https://doi.org/10.1038/modpathol.2016.152. 2012;28:43541. Reported cases involve the conjunctiva, liver, gastrointestinal tract, stomach, lungs, paranasal sinuses, and many cutaneous areas. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Healy JA, Dave SS. Lee ES, Kim LH, Abdullah WA, Peh SC. 1, pp. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. Pictorial review: principles of double-contrast pharyngography. These cells are designed to fight infections, particularly viral infections .. https://doi.org/10.1038/modpathol.2011.45. In summary, NHLs in the base of the tongue are rare with nonspecific symptoms of oropharyngeal discomfort, and they could present with normal-like mucosal surfaces. Expression of c-Myc and p53 correlates with clinical outcome in diffuse large B-cell lymphomas. Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue swellings: a study of 75 cases. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. 1970 Dec;8(3):413-24. After washing and amplification, target RNA was stained with DAB. Google Scholar. J Laryngol Otol. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. Surgical debulking/excision is the treatment of choice. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Diagn Cytopathol. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Six of the cases exhibited tongue base masses with smooth surface membranes. A poor prognostic case of peripheral T-cell lymphoma in the base of tongue with chemotherapy followed by radiation therapy. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. In terms of pathological characteristics, 6 patients were diagnosed with B-cell NHL, and 1 patient was diagnosed with PTCL, NOS (Table2). Her chemotherapy regimen was changed to GDP. Privacy The condition mainly affects adult patients, ranging. Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida. Nathu RM, Mendenhall NP, Almasri NM, Lynch JW. Tumour cells expressed CD3, CD4, and CD5. 2017;118:6028. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. PubMed Pribuisiene R, Uloza V, Siupsinskiene N, Butkus E, Kupcinskas L. Al-Asoom L, Al-Rubaish AM, El-Munshid HA, Al-Nafaie AN, Bukharie HA, Abdulrahman IS. Lymphoma cases were selected from 2010 to 2017 in PUMCH, and all cases were reviewed to identify lymphomas arising from the base of the tongue instead of other primary sites. Nuclei were counterstained with hematoxylin. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Diagnostic Pathology Lopez-Guillermo et al. Bookshelf This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. ZL, BW, XR and YC reviewed all the cases together. a. CT showed a well-bordered cystic mass. When oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether abnormalities are present. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. Like all lymphoid tissue in the body, oral lymphoid tissue is highly reactive and can enlarge from time to time as it reacts to foreign entities. Unauthorized use of these marks is strictly prohibited. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. This report adds valuable knowledge to the possible virus infection status of tongue NHL, due to its rare occurrence. 2009 Sep;114(6):948-59. doi: 10.1007/s11547-009-0416-4. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Shiozawa E, Takimoto M, Makino R, Adachi D, Saito B, Yamochi-Onizuka T, Yamochi T, Shimozuma J, Maeda T, Kohno Y, Kawakami K, Nakamaki T, Tomoyasu S, et al. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. All rights reserved. A lymphoid follicle under microscope is shown in Figure 2. https://www.linkedin.com/showcase/4000114/. Figure 2 shows the process of a reactive lymphoid lesion histologically. Not applicable. She started rituximab-CHOP(R-CHOP) regimen. XR and YC wrote the article. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. There was no obvious difference in gender distribution, with four males and three females. Mod Pathol. 2, pp. 2006;17:143440. https://doi.org/10.1002/cncr.27988. Understanding the biological behavior of and therapeutic options for tongue lymphoma is difficult due to the paucity of cases. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. Among our cases, there were 1 GC and 3 NGC cases. 5760, 1993. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. f. Ki-67 staining of the tumour cells (200x). The outer cortex is composed of follicles of B cells so that it is called the B-cell zone. An official website of the United States government. government site. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . Unable to load your collection due to an error, Unable to load your delegates due to an error. Lymphoid hyperplasia at the base of the tongue. Tracheotomy was performed to relieve respiratory oppression. Cookies policy. 2014;10:94550. the ENT DR was lovely. 2005;23:2797804. https://doi.org/10.22034/APJCP.2017.18.10.2781. volume15, Articlenumber:30 (2020) Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. 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